Title : LH-21 and abnormal cannabidiol improve β-cell function in isolated human and mouse islets through GPR55-dependent and -independent signalling.

Pub. Date : 2018 Apr

PMID : 29205751






3 Functional Relationships(s)
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1 LH-21 and abnormal cannabidiol improve beta-cell function in isolated human and mouse islets through GPR55-dependent and -independent signalling. Cannabidiol G protein-coupled receptor 55 Mus musculus
2 Abn-CBD and LH-21 reduced cytokine-induced apoptosis in human islets and GPR55+/+ mouse islets, and these effects were suppressed after GPR55 deletion. 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol G protein-coupled receptor 55 Mus musculus
3 They also increased beta-cell proliferation: the effects of Abn-CBD were preserved in islets from GPR55-/- mice, while those of LH-21 were abolished. 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol G protein-coupled receptor 55 Mus musculus