Title : ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase.

Pub. Date : 2017 Oct

PMID : 29031715






3 Functional Relationships(s)
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1 Deficiency in either ANGPTL3 or ANGPTL8 reduces plasma triglyceride levels and increases LPL activity, whereas overexpression of either protein does the opposite. Triglycerides angiopoietin-like 3 Mus musculus
2 Recent studies suggest that ANGPTL8 may functionally interact with ANGPTL3 to alter clearance of plasma triglycerides; however, the nature of this interaction has remained elusive. Triglycerides angiopoietin-like 3 Mus musculus
3 Adenovirus experiments showed that 2-fold overexpression of ANGPTL3 significantly increased plasma triglycerides only in the presence of ANGPTL8. Triglycerides angiopoietin-like 3 Mus musculus