Pub. Date : 1988 Aug 15
PMID : 2902847
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of 2,6-dichloro-4-nitrophenol (DCNP), an inhibitor of phenol sulphotransferases (EC 2.8.2.-), on the biosynthesis of aminopeptidase N (EC 3.4.11.2) was studied in organ-cultured pig intestinal mucosal explants. | 2,6-dichloro-4-nitrophenol | alanyl aminopeptidase, membrane | Sus scrofa |
| 2 | The effect of 2,6-dichloro-4-nitrophenol (DCNP), an inhibitor of phenol sulphotransferases (EC 2.8.2.-), on the biosynthesis of aminopeptidase N (EC 3.4.11.2) was studied in organ-cultured pig intestinal mucosal explants. | 2,6-dichloro-4-nitrophenol | alanyl aminopeptidase, membrane | Sus scrofa |
| 3 | At 50 microM DCNP did not affect protein synthesis but it decreased incorporation of [35S]sulphate into aminopeptidase N and other major microvillar hydrolases by 70-85% compared with controls, indicating an inhibition of their post-translational tyrosine sulphation. | 2,6-dichloro-4-nitrophenol | alanyl aminopeptidase, membrane | Sus scrofa |
| 4 | At 50 microM DCNP did not affect protein synthesis but it decreased incorporation of [35S]sulphate into aminopeptidase N and other major microvillar hydrolases by 70-85% compared with controls, indicating an inhibition of their post-translational tyrosine sulphation. | Sulfates | alanyl aminopeptidase, membrane | Sus scrofa |
| 5 | In labelling experiments with [35S]methionine from 0.5 to 5 h, DCNP was tested for its possible influence on synthesis, processing and microvillar expression of aminopeptidase N, but no effect on any of these parameters could be detected. | 2,6-dichloro-4-nitrophenol | alanyl aminopeptidase, membrane | Sus scrofa |