Pub. Date : 2017 Nov 15
PMID : 28990606
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A combined docosahexaenoic acid-thyroid hormone protocol upregulates rat liver beta-Klotho expression and downstream components of FGF21 signaling as a potential novel approach to metabolic stress conditions. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 2 | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 3 | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 4 | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 5 | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 6 | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. | Triiodothyronine | fibroblast growth factor 21 | Rattus norvegicus |
| 7 | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. | Triiodothyronine | fibroblast growth factor 21 | Rattus norvegicus |
| 8 | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. | Triiodothyronine | fibroblast growth factor 21 | Rattus norvegicus |
| 9 | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. | Triiodothyronine | fibroblast growth factor 21 | Rattus norvegicus |
| 10 | Combined DHA (daily doses of 300 mg kg-1 for 3 days)-T3 (0.05 mg kg-1 at the fourth day) administration elicited higher levels of liver DHA and serum T3, with enhanced hepatic nuclear/cytosolic PPARalpha ratios, upregulation of FGF21 and beta-Klotho expression, and a small reduction in that of FGF receptor 1 (FGFR1), compared with the respective controls. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 11 | The upregulation of liver PPARalpha-FGF21-AMPK signaling by the combined DHA-T3 protocol resulted in values significantly higher than those elicited by the addition of the data obtained for DHA and T3 alone. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 12 | The upregulation of liver PPARalpha-FGF21-AMPK signaling by the combined DHA-T3 protocol resulted in values significantly higher than those elicited by the addition of the data obtained for DHA and T3 alone. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 13 | It is concluded that combined DHA-T3 supplementation achieves synergistic effects on liver PPARalpha-FGF21-AMPK signaling, which may result in significant metabolic changes associated with energy expenditure that are of importance in the treatment of obesity and other metabolic disorders. | Docosahexaenoic Acids | fibroblast growth factor 21 | Rattus norvegicus |
| 14 | It is concluded that combined DHA-T3 supplementation achieves synergistic effects on liver PPARalpha-FGF21-AMPK signaling, which may result in significant metabolic changes associated with energy expenditure that are of importance in the treatment of obesity and other metabolic disorders. | Triiodothyronine | fibroblast growth factor 21 | Rattus norvegicus |