Pub. Date : 2018 Jan
PMID : 28971229
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of the guanine nucleotide binding protein, Galphao, in the development of morphine tolerance and dependence. | Morphine | guanine nucleotide binding protein, alpha O | Mus musculus |
| 2 | Evidence suggests that the antinociceptive effects of morphine are mediated by Galphao. | Morphine | guanine nucleotide binding protein, alpha O | Mus musculus |
| 3 | However, the role of Galphao in the development of morphine tolerance and dependence is unknown. | Morphine | guanine nucleotide binding protein, alpha O | Mus musculus |
| 4 | OBJECTIVE: The objective of the study is to evaluate the contribution of Galphao to the development of morphine tolerance and dependence in mice. | Morphine | guanine nucleotide binding protein, alpha O | Mus musculus |
| 5 | With chronic morphine treatment, Galphao +/- mice developed tolerance faster and displayed more severe naltrexone-precipitated withdrawal in some behaviors than did wild-type littermates. | Morphine | guanine nucleotide binding protein, alpha O | Mus musculus |
| 6 | With chronic morphine treatment, Galphao +/- mice developed tolerance faster and displayed more severe naltrexone-precipitated withdrawal in some behaviors than did wild-type littermates. | Naltrexone | guanine nucleotide binding protein, alpha O | Mus musculus |
| 7 | CONCLUSIONS: These data suggest that the guanine nucleotide binding protein Galphao offers some protection against the development of morphine tolerance and dependence. | Guanine Nucleotides | guanine nucleotide binding protein, alpha O | Mus musculus |
| 8 | CONCLUSIONS: These data suggest that the guanine nucleotide binding protein Galphao offers some protection against the development of morphine tolerance and dependence. | Morphine | guanine nucleotide binding protein, alpha O | Mus musculus |