Pub. Date : 2017 Nov
PMID : 28837879
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Telmisartan ameliorates adipoR1 and adipoR2 expression via PPAR-gamma activation in the coronary artery and VSMCs. | Telmisartan | adiponectin receptor 1 | Rattus norvegicus |
| 2 | Interestingly, telmisartan or GW1929 also prevented hyperglycemia-induced downregulation of AdipoR1 and AdipoR2 expression. | Telmisartan | adiponectin receptor 1 | Rattus norvegicus |
| 3 | Interestingly, telmisartan or GW1929 also prevented hyperglycemia-induced downregulation of AdipoR1 and AdipoR2 expression. | GW 1929 | adiponectin receptor 1 | Rattus norvegicus |
| 4 | Additionally, GW9662 (PPAR-gamma antagonist) significantly decreased the effects of telmisartan on AdipoR1 and AdipoR2 expression. | 2-chloro-5-nitrobenzanilide | adiponectin receptor 1 | Rattus norvegicus |
| 5 | Additionally, GW9662 (PPAR-gamma antagonist) significantly decreased the effects of telmisartan on AdipoR1 and AdipoR2 expression. | Telmisartan | adiponectin receptor 1 | Rattus norvegicus |
| 6 | These results demonstrated that telmisartan effectively ameliorated coronary insulin resistance and inflammation in diabetic rats and upregulated AdipoR1/R2 expression via activation of PPAR-gamma in the coronary artery and VSMCs. | Telmisartan | adiponectin receptor 1 | Rattus norvegicus |