Title : Lysophosphatidic acid directly induces macrophage-derived foam cell formation by blocking the expression of SRBI.

Pub. Date : 2017 Sep 23

PMID : 28765047






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Furthermore, the LPA1/3 receptor antagonist Ki16425 significantly abolished the LPA effects, indicating that LPA1/3 was involved in the foam cell formation and SRBI expression induced by LPA. 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid lysophosphatidic acid receptor 1 Mus musculus
2 Furthermore, the LPA1/3 receptor antagonist Ki16425 significantly abolished the LPA effects, indicating that LPA1/3 was involved in the foam cell formation and SRBI expression induced by LPA. lysophosphatidic acid lysophosphatidic acid receptor 1 Mus musculus
3 Furthermore, the LPA1/3 receptor antagonist Ki16425 significantly abolished the LPA effects, indicating that LPA1/3 was involved in the foam cell formation and SRBI expression induced by LPA. lysophosphatidic acid lysophosphatidic acid receptor 1 Mus musculus
4 Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1/3 -AKT activation and subsequent SRBI expression. lysophosphatidic acid lysophosphatidic acid receptor 1 Mus musculus