Title : Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells.

Pub. Date : 2017 Oct

PMID : 28731156






3 Functional Relationships(s)
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1 The present study demonstrated that glutamate-induced exocytosis was increased in beta cells derived from PICK1-knockout mice. Glutamic Acid protein interacting with C kinase 1 Mus musculus
2 In agreement with this result, adding PICK1 in beta cells reduced glutamate-induced exocytosis, whereas adding EVKI, a peptide that interrupts the interaction between AMPARs and PICK1, increased the exocytosis of beta cells with the application of glutamate. Glutamic Acid protein interacting with C kinase 1 Mus musculus
3 Taken together, the results indicate that PICK1 regulates glutamate-induced exocytosis in beta cells. Glutamic Acid protein interacting with C kinase 1 Mus musculus