Title : Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma.

Pub. Date : 2017 Dec 1

PMID : 28655161






1 Functional Relationships(s)
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1 Two members of DNB, PLA2G6 and CYP2C44, along with their associated differentially expressed proteins, were found to induce dysfunction of arachidonic acid metabolism, further activate inflammatory responses through inflammatory mediator regulation of transient receptor potential channels, and finally lead to impairments of liver detoxification and malignant transition to cancer. Arachidonic Acid cytochrome P450, family 2, subfamily c, polypeptide 23 Mus musculus