Title : Folate deficiency disturbs hsa-let-7 g level through methylation regulation in neural tube defects.

Pub. Date : 2017 Dec

PMID : 28631291






4 Functional Relationships(s)
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1 Among the findings, there was a significant association between folic acid concentration and hsa-let-7 g methylation level in NTD cases. Folic Acid microRNA let-7g Homo sapiens
2 Overexpression of hsa-let-7 g, along with its target genes, disturbed the migration and proliferation of SK-N-SH cells, implying that hsa-let-7 g plays important roles in the prevention of NTDs by folic acid. Folic Acid microRNA let-7g Homo sapiens
3 Overexpression of hsa-let-7 g, along with its target genes, disturbed the migration and proliferation of SK-N-SH cells, implying that hsa-let-7 g plays important roles in the prevention of NTDs by folic acid. Folic Acid microRNA let-7g Homo sapiens
4 In summary, our data suggest a relationship between aberrant methylation of hsa-let-7 g and disturbed folate metabolism in NTDs, implying that improvements in nutrition during early pregnancy may prevent such defects, possibly via the donation of methyl groups for miRNAs. Folic Acid microRNA let-7g Homo sapiens