Title : Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.

Pub. Date : 2017 Jun

PMID : 28615142






2 Functional Relationships(s)
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1 Significant prolongation of paced action potential duration in KCNJ2-transduced hiPSC-derived cardiomyocytes was stably measured at 0.1 muM E-4031, although the same concentration of E-4031 ablated firing of non-treated hiPSC-derived cardiomyocytes. E 4031 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens
2 Significant prolongation of paced action potential duration in KCNJ2-transduced hiPSC-derived cardiomyocytes was stably measured at 0.1 muM E-4031, although the same concentration of E-4031 ablated firing of non-treated hiPSC-derived cardiomyocytes. E 4031 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens