Title : Alteration of the extracellular matrix of smooth muscle cells by ascorbate treatment.

Pub. Date : 1985 Jun 18

PMID : 2859894






8 Functional Relationships(s)
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1 The influence of ascorbate on insoluble elastin and collagen has been described. Ascorbic Acid elastin Rattus norvegicus
2 In the presence of ascorbate, the amount of insoluble collagen increases, while the insoluble elastin content is significantly less. Ascorbic Acid elastin Rattus norvegicus
3 When ascorbate conditions are varied at different times during the culture, the extracellular matrices are altered with respect to collagen and elastin ratios. Ascorbic Acid elastin Rattus norvegicus
4 The decrease in elastin accumulation in the presence of ascorbate may be explained by an overhydroxylation of tropoelastin. Ascorbic Acid elastin Rattus norvegicus
5 The decrease in elastin accumulation in the presence of ascorbate may be explained by an overhydroxylation of tropoelastin. Ascorbic Acid elastin Rattus norvegicus
6 Approximately 1/3 of the prolyl residues in the soluble elastin fractions isolated from cultures grown in the presence of ascorbate are hydroxylated. Peptide oostatic hormone elastin Rattus norvegicus
7 Approximately 1/3 of the prolyl residues in the soluble elastin fractions isolated from cultures grown in the presence of ascorbate are hydroxylated. Ascorbic Acid elastin Rattus norvegicus
8 Since the insoluble elastin accumulated in these cultures contain the unique lysine-derived cross-links in amounts comparable to aortic tissue, this culture system proves ideal for studying the influence of extracellular matrix elastin on cell growth and metabolism. Lysine elastin Rattus norvegicus