Title : Prostaglandin E2 inhibits the activation of cloned T cell hybridomas.

Pub. Date : 1985 Apr

PMID : 2857750






3 Functional Relationships(s)
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1 Physiologic concentrations of PGE2 inhibited the induction of IL 2 secretion by the T cell hybridomas tested, when they were activated either by TA3 cells or by mitogenic signals. Dinoprostone RIKEN cDNA 2700049A03 gene Mus musculus
2 The direct addition of dibutyryl cAMP (dcAMP) to cultures of E8.A1 cells resulted in marked inhibition of IL 2 secretion when stimulated by TA3 or by mitogenic signals, with an average of 80% inhibition occurring at 10(-4) M dcAMP. Bucladesine RIKEN cDNA 2700049A03 gene Mus musculus
3 The direct addition of dibutyryl cAMP (dcAMP) to cultures of E8.A1 cells resulted in marked inhibition of IL 2 secretion when stimulated by TA3 or by mitogenic signals, with an average of 80% inhibition occurring at 10(-4) M dcAMP. Bucladesine RIKEN cDNA 2700049A03 gene Mus musculus