Pub. Date : 1988 Jul
PMID : 2836258
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calmodulin-mediated effects of loperamide on chloride transport by brush border membrane vesicles from human ileum. | Loperamide | calmodulin 1 | Homo sapiens |
| 2 | In addition, we studied the role of Ca2+/calmodulin in the action of loperamide on chloride transport by human BBMVs. | Loperamide | calmodulin 1 | Homo sapiens |
| 3 | In loperamide-pretreated BBMVs, calmodulin activity was significantly decreased (12 +/- 2 vs. 38 +/- 4 pmol/mg protein). | Loperamide | calmodulin 1 | Homo sapiens |
| 4 | When loperamide-pretreated vesicles were incubated with 2 microM calcium (free concentration) plus 5 microM calmodulin for 1 h at 5 degrees C, complete inhibition of the stimulatory effect of loperamide on Cl-/OH- antiport and Na+/Cl- cotransport was observed. | Loperamide | calmodulin 1 | Homo sapiens |
| 5 | When loperamide-pretreated vesicles were incubated with 2 microM calcium (free concentration) plus 5 microM calmodulin for 1 h at 5 degrees C, complete inhibition of the stimulatory effect of loperamide on Cl-/OH- antiport and Na+/Cl- cotransport was observed. | Loperamide | calmodulin 1 | Homo sapiens |
| 6 | Increasing the Ca2+/calmodulin activity of loperamide-pretreated BBMVs with 2 microM calcium plus 5 microM calmodulin led to a significant inhibition of Cl-/OH- antiport and Na+/Cl- cotransport by 40% +/- 5% (p less than 0.005). | Loperamide | calmodulin 1 | Homo sapiens |
| 7 | Increasing the Ca2+/calmodulin activity of loperamide-pretreated BBMVs with 2 microM calcium plus 5 microM calmodulin led to a significant inhibition of Cl-/OH- antiport and Na+/Cl- cotransport by 40% +/- 5% (p less than 0.005). | Loperamide | calmodulin 1 | Homo sapiens |