Pub. Date : 2017 May
PMID : 28339090
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of farnesyl pyrophosphate synthase attenuates high glucose-induced vascular smooth muscle cells proliferation. | Glucose | farnesyl diphosphate synthetase | Mus musculus |
| 2 | Our previous studies found that farnesyl pyrophosphate synthase (FPPS, EC 2.5.1.10), an essential enzyme in the mevalonate pathway, was upregulated in aorta media from diabetic mice along with the process of atherosclerosis. | Mevalonic Acid | farnesyl diphosphate synthetase | Mus musculus |
| 3 | Our previous studies found that farnesyl pyrophosphate synthase (FPPS, EC 2.5.1.10), an essential enzyme in the mevalonate pathway, was upregulated in aorta media from diabetic mice along with the process of atherosclerosis. | Mevalonic Acid | farnesyl diphosphate synthetase | Mus musculus |
| 4 | However, the exact role of FPPS in high glucose-induced proliferation of VSMCs is largely unclear. | Glucose | farnesyl diphosphate synthetase | Mus musculus |
| 5 | In our study, we found that alendronate (an FPPS inhibitor) attenuated diabetic accelerated atherosclerosis in vivo and suppressed high glucose-induced VSMCs proliferation in vitro. | Alendronate | farnesyl diphosphate synthetase | Mus musculus |
| 6 | In our study, we found that alendronate (an FPPS inhibitor) attenuated diabetic accelerated atherosclerosis in vivo and suppressed high glucose-induced VSMCs proliferation in vitro. | Glucose | farnesyl diphosphate synthetase | Mus musculus |
| 7 | In conclusion, FPPS inhibition by alendronate attenuated the high glucose-induced proliferation of VSMCs both in vivo and in vitro, probably though depressing H2S metabolism and suppressing small GTPases (Ras, RhoA, and Rac1) activation. | Alendronate | farnesyl diphosphate synthetase | Mus musculus |
| 8 | In conclusion, FPPS inhibition by alendronate attenuated the high glucose-induced proliferation of VSMCs both in vivo and in vitro, probably though depressing H2S metabolism and suppressing small GTPases (Ras, RhoA, and Rac1) activation. | Glucose | farnesyl diphosphate synthetase | Mus musculus |