Pub. Date : 2017 Jun
PMID : 28258011
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities. | mir-16 | forkhead box O1 | Gallus gallus |
| 2 | Here, we reported that miR-16 inhibited myoblast proliferation and promoted myoblast apoptosis by directly targeting Bcl2 and FOXO1. | mir-16 | forkhead box O1 | Gallus gallus |
| 3 | Bioinformatic and biochemical analyses revealed Bcl2 and FOXO1 as direct targets of miR-16. | mir-16 | forkhead box O1 | Gallus gallus |
| 4 | Consist to the effect of miR-16 on myogenesis, specific inhibition of Bcl2 or FOXO1 significantly suppressed myoblast proliferation and induced myoblast apoptosis, indicating that both Bcl2 and FOXO1 contributed to miR-16 regulatory function in myogenesis. | mir-16 | forkhead box O1 | Gallus gallus |
| 5 | Consist to the effect of miR-16 on myogenesis, specific inhibition of Bcl2 or FOXO1 significantly suppressed myoblast proliferation and induced myoblast apoptosis, indicating that both Bcl2 and FOXO1 contributed to miR-16 regulatory function in myogenesis. | mir-16 | forkhead box O1 | Gallus gallus |
| 6 | Interestingly, FOXO1, as the core target, mediated multiple growth-related pathways induced by miR-16 such as PI3K-AKT-MAPK and PI3K-AKT-mTOR. | mir-16 | forkhead box O1 | Gallus gallus |
| 7 | These findings have provided a novel mechanism whereby miR-16 represses Bcl2 and FOXO1 expression to maintain myoblast growth and skeletal muscle mass. | mir-16 | forkhead box O1 | Gallus gallus |