Title : Dynamics of Atg5-Atg12-Atg16L1 Aggregation and Deaggregation.

Pub. Date : 2017

PMID : 28253959






2 Functional Relationships(s)
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1 The execution of canonical autophagy is regulated by a core signaling cascade and it involves two well-characterized, ubiquitin-like conjugation systems-the Atg5/Atg12/Atg16L1 and the Atg8-phosphatidyl ethanolamine (PE), which are both catalyzed by Atg7. pe autophagy related 12 Homo sapiens
2 The conjugation of Atg5-Atg12 and the subsequent interaction with the positive regulator Atg16L1 are essential for the conjugation of Atg8 to PE and the subsequent formation of autophagosomes. pe autophagy related 12 Homo sapiens