Pub. Date : 2017 Jun 1
PMID : 28229459
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Current-clamp experiments demonstrate that serotonergic afferents are largely excitatory for mitral cells (MCs) in the MOB where 5-HT2A receptors mediate a direct excitatory action. | mcs | sphingomyelin synthase 1 | Mus musculus |
| 2 | Differential 5-HT neuromodulation of MCs across the MOB and AOB could contribute to select behaviours such as olfactory learning or aggression. | mcs | sphingomyelin synthase 1 | Mus musculus |
| 3 | ABSTRACT: Mitral cells (MCs) contained in the main (MOB) and accessory (AOB) olfactory bulb have distinct intrinsic membrane properties but the extent of neuromodulation across the two systems has not been widely explored. | mcs | sphingomyelin synthase 1 | Mus musculus |
| 4 | Herein, we investigated a widely distributed CNS modulator, serotonin (5-HT), for its ability to modulate the biophysical properties of MCs across the MOB and AOB, using an in vitro, brain slice approach in postnatal 15-30 day mice. | Serotonin | sphingomyelin synthase 1 | Mus musculus |
| 5 | Herein, we investigated a widely distributed CNS modulator, serotonin (5-HT), for its ability to modulate the biophysical properties of MCs across the MOB and AOB, using an in vitro, brain slice approach in postnatal 15-30 day mice. | mcs | sphingomyelin synthase 1 | Mus musculus |
| 6 | Albeit located in parallel partitions of the olfactory system, 5-HT largely elicited MC excitation in the MOB while it evoked two different kinetic rates of MC inhibition in the AOB. | Methylcholanthrene | sphingomyelin synthase 1 | Mus musculus |
| 7 | Using a combination of pharmacological agents, we found that the MC excitatory responses in the MOB were mediated by 5-HT2A receptors through a direct activation. | Methylcholanthrene | sphingomyelin synthase 1 | Mus musculus |
| 8 | The distinct serotonergic modulation of MCs between the MOB and AOB could provide a molecular basis for differential chemosensory behaviours driven by the brainstem raphe nuclei into these parallel systems. | mcs | sphingomyelin synthase 1 | Mus musculus |