Title : Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.

Pub. Date : 2017 May

PMID : 28226201






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Loss of function of the RYR3 ortholog reduced EtOH sensitivity in C. elegans and rapid tolerance in Drosophila. Ethanol ryanodine receptor 3 Homo sapiens
2 Despite nonreplication of COL6A3, KLF12, and RYR3 signals, orthologs of these genes influence behavioral response to EtOH in MOs, suggesting potential involvement in human EtOH response and AD liability. Ethanol ryanodine receptor 3 Homo sapiens
3 Despite nonreplication of COL6A3, KLF12, and RYR3 signals, orthologs of these genes influence behavioral response to EtOH in MOs, suggesting potential involvement in human EtOH response and AD liability. Ethanol ryanodine receptor 3 Homo sapiens