Title : Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.

Pub. Date : 2017 May

PMID : 28083634






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Otub1 directly affected Lys48-linked Tau deubiquitination, impairing Tau degradation, dependent on its catalytically active cysteine, but independent of its noncanonical pathway modulated by its N-terminal domain in primary neurons. Cysteine OTU domain, ubiquitin aldehyde binding 1 Mus musculus