Title : Fluorescent Branched RNAs for High-Throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition.

Pub. Date : 2017 Mar 17

PMID : 28055181






2 Functional Relationships(s)
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1 We show that unlabeled bRNAs with non-native 2",5"-phosphodiester linkages, such as phosphoramidate or phosphorothioate, can inhibit Dbr1-mediated debranching with IC50 values in the low nanomolar range. phosphoramidic acid debranching RNA lariats 1 Homo sapiens
2 We show that unlabeled bRNAs with non-native 2",5"-phosphodiester linkages, such as phosphoramidate or phosphorothioate, can inhibit Dbr1-mediated debranching with IC50 values in the low nanomolar range. Parathion debranching RNA lariats 1 Homo sapiens