Pub. Date : 2016 Oct 25
PMID : 27626499
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. | rottlerin | cell division cycle 20 | Homo sapiens |
| 2 | Mechanistically, the expression of Cdc20 oncoprotein was measured by the RT-PCR and Western blot analysis in glioma cells treated with rottlerin. | rottlerin | cell division cycle 20 | Homo sapiens |
| 3 | We observed that rottlerin significantly inhibited the expression of Cdc20 in glioma cells, implying that Cdc20 could be a novel target of rottlerin. | rottlerin | cell division cycle 20 | Homo sapiens |
| 4 | We observed that rottlerin significantly inhibited the expression of Cdc20 in glioma cells, implying that Cdc20 could be a novel target of rottlerin. | rottlerin | cell division cycle 20 | Homo sapiens |
| 5 | We observed that rottlerin significantly inhibited the expression of Cdc20 in glioma cells, implying that Cdc20 could be a novel target of rottlerin. | rottlerin | cell division cycle 20 | Homo sapiens |
| 6 | We observed that rottlerin significantly inhibited the expression of Cdc20 in glioma cells, implying that Cdc20 could be a novel target of rottlerin. | rottlerin | cell division cycle 20 | Homo sapiens |
| 7 | In line with this, over-expression of Cdc20 decreased rottlerin-induced cell growth inhibition and apoptosis, whereas down-regulation of Cdc20 by its shRNA promotes rottlerin-induced anti-tumor activity. | rottlerin | cell division cycle 20 | Homo sapiens |
| 8 | In line with this, over-expression of Cdc20 decreased rottlerin-induced cell growth inhibition and apoptosis, whereas down-regulation of Cdc20 by its shRNA promotes rottlerin-induced anti-tumor activity. | rottlerin | cell division cycle 20 | Homo sapiens |
| 9 | Our findings indicted that rottlerin could exert its tumor suppressive function by inhibiting Cdc20 pathway which is constitutively active in glioma cells. | rottlerin | cell division cycle 20 | Homo sapiens |
| 10 | Therefore, down-regulation of Cdc20 by rottlerin could be a promising therapeutic strategy for the treatment of glioma. | rottlerin | cell division cycle 20 | Homo sapiens |