Pub. Date : 2016 Sep 21
PMID : 27529405
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 6-Bromo-7-hydroxy-3-methylcoumarin (mBhc) is an efficient multi-photon labile protecting group for thiol caging and three-dimensional chemical patterning. | 6-bromo-7-hydroxy-3-methylcoumarin | PHD finger protein 21A | Mus musculus |
| 2 | 6-Bromo-7-hydroxy-3-methylcoumarin (mBhc) is an efficient multi-photon labile protecting group for thiol caging and three-dimensional chemical patterning. | Sulfhydryl Compounds | PHD finger protein 21A | Mus musculus |
| 3 | To address this issue, here we describe the development of 6-bromo-7-hydroxy-3-methylcoumarin-4-ylmethyl (mBhc) as an improved group for thiol-protection. | 6-bromo-7-hydroxy-3-methylcoumarin-4-ylmethyl | PHD finger protein 21A | Mus musculus |
| 4 | To address this issue, here we describe the development of 6-bromo-7-hydroxy-3-methylcoumarin-4-ylmethyl (mBhc) as an improved group for thiol-protection. | Sulfhydryl Compounds | PHD finger protein 21A | Mus musculus |
| 5 | One- and two-photon photolysis reactions demonstrate that a peptide containing a mBhc-caged thiol undergoes clean and efficient photo-cleavage upon irradiation without detectable photoisomer production. | Sulfhydryl Compounds | PHD finger protein 21A | Mus musculus |
| 6 | To test its utility for biological studies, a K-Ras-derived peptide containing an mBhc-protected thiol was prepared by solid phase peptide synthesis using Fmoc-Cys(mBhc)-OH for the introduction of the caged thiol. | Sulfhydryl Compounds | PHD finger protein 21A | Mus musculus |
| 7 | To show the utility of this caging group in biomaterial applications, we covalently modified hydrogels with mBhc-protected cysteamine. | Cysteamine | PHD finger protein 21A | Mus musculus |
| 8 | The simple synthesis of mBhc and its efficient removal by one- and two-photon processes make it an attractive protecting group for thiol caging in a variety of applications. | Sulfhydryl Compounds | PHD finger protein 21A | Mus musculus |