Title : The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages.

Pub. Date : 2016 Aug

PMID : 27178323






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The LPAR blocker Ki16425 (cells, 10 muM; lungs, 25 muM; Ki, 0.34 muM) or cellular knockdown of LPAR type 1 decreased oxidant generation and blocked translocation of rac1 to plasma membrane. 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid lysophosphatidic acid receptor 1 Mus musculus