Pub. Date : 2016 Jul 28
PMID : 27126361
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ARK5 promotes doxorubicin resistance in hepatocellular carcinoma via epithelial-mesenchymal transition. | Doxorubicin | NUAK family kinase 1 | Homo sapiens |
| 2 | In this study, we found that SNU387 and SNU449 HCC cell lines overexpressing ARK5 displayed low doxorubicin sensitivity compared to Huh7 and Hep3B HCC cell lines with ARK5 low-expression. | Doxorubicin | NUAK family kinase 1 | Homo sapiens |
| 3 | And knockdown of ARK5 increased the doxorubicin sensitivity in all HCC cell lines in the manner of inhibiting cell proliferation. | Doxorubicin | NUAK family kinase 1 | Homo sapiens |
| 4 | Moreover, suppressing ARK5 by siRNA restored E-cadherin and vimentin expression induced by doxorubicin treatment or hypoxia culture. | Doxorubicin | NUAK family kinase 1 | Homo sapiens |
| 5 | Our results indicated ARK5 confers doxorubicin resistance in HCC via inducing EMT. | Doxorubicin | NUAK family kinase 1 | Homo sapiens |