Pub. Date : 2016 May 9
PMID : 27029378
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we developed self-cross-linked biodegradable poly(ethylene glycol)-b-poly(l-lysine)-b-poly(l-cysteine) (LCss) polypeptide nanoparticles to codeliver DOX and miR-129-5p, which aimed to overcome MDR in cancer cells. | poly(ethylene glycol)-b-poly(l-lysine)-b-poly(l-cysteine) | microRNA 1295a | Homo sapiens |
| 2 | The codelivery of miR-129-5p and DOX with LCss (DLCss/miR) significantly increased miR-129-5p expression over 100-fold in MCF-7/ADR cells, which effectively overcame MDR by directly inhibiting P-glycoprotein (P-gp), thereby increasing intracellular DOX accumulation and cytotoxicity in MCF-7/ADR cells. | Doxorubicin | microRNA 1295a | Homo sapiens |
| 3 | The codelivery of miR-129-5p and DOX with LCss (DLCss/miR) significantly increased miR-129-5p expression over 100-fold in MCF-7/ADR cells, which effectively overcame MDR by directly inhibiting P-glycoprotein (P-gp), thereby increasing intracellular DOX accumulation and cytotoxicity in MCF-7/ADR cells. | Doxorubicin | microRNA 1295a | Homo sapiens |
| 4 | Furthermore, miR-129-5p also partially diminished cyclin-dependent kinase 6 (CDK6), and synergized with DOX to simultaneously decrease S phase and induce G2 phase cell cycle arrest, thereby further enhancing the chemosensitivity of MCF-7/ADR cells. | Doxorubicin | microRNA 1295a | Homo sapiens |