Title : MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion.

Pub. Date : 2017 May

PMID : 26993299






4 Functional Relationships(s)
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1 Here, we show that CBH significantly increased the number of autophagic vacuoles (AVs) with high LC3-II levels, but decreased SQSTM1 and cathepsin D levels in the hippocampi of rats following bilateral common carotid artery occlusion (2VO) for 2 weeks. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE sequestosome 1 Rattus norvegicus
2 Here, we show that CBH significantly increased the number of autophagic vacuoles (AVs) with high LC3-II levels, but decreased SQSTM1 and cathepsin D levels in the hippocampi of rats following bilateral common carotid artery occlusion (2VO) for 2 weeks. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE cathepsin D Rattus norvegicus
3 The results revealed that CBH in rats at 2 weeks could induce inefficient lysosomal clearance, which is regulated by the Mir27a-mediated downregulation of LAMP-2 protein expression. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE microRNA 27a Rattus norvegicus
4 The results revealed that CBH in rats at 2 weeks could induce inefficient lysosomal clearance, which is regulated by the Mir27a-mediated downregulation of LAMP-2 protein expression. S-(D-CARBOXYBUTYL)-L-HOMOCYSTEINE lysosomal-associated membrane protein 2 Rattus norvegicus