Title : Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway.

Pub. Date : 2016 Jun

PMID : 26969487






4 Functional Relationships(s)
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1 Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. stearic acid microRNA 615 Mus musculus
2 RESULTS: In both mouse islets and cultured rat insulinoma INS-1 cells, stearic acid exhibited a stronger lipotoxic role than other fatty acids, owing to repression of B cell CLL/lymphoma 2 (BCL-2) and BCL-2-like 2 (BCL-W) by stearic acid stimulation of miR-34a-5p. stearic acid microRNA 615 Mus musculus
3 Further investigations in INS-1 cells revealed that p53 was involved in stearic-acid-induced elevation of miR-34a-5p, owing in part to activation of protein kinase-like endoplasmic reticulum kinase (PERK). stearic acid microRNA 615 Mus musculus
4 Conversely, silencing PERK alleviated stearic-acid-induced p53, miR-34a-5p and lipotoxicity. stearic acid microRNA 615 Mus musculus