Title : Activation of NADPH-recycling systems in leaves and roots of Arabidopsis thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix hydrolase 19 (AtNUDX19) gene.

Pub. Date : 2016 Mar 15

PMID : 26878367






8 Functional Relationships(s)
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1 Activation of NADPH-recycling systems in leaves and roots of Arabidopsis thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix hydrolase 19 (AtNUDX19) gene. NADP nudix hydrolase homolog 19 Arabidopsis thaliana
2 Activation of NADPH-recycling systems in leaves and roots of Arabidopsis thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix hydrolase 19 (AtNUDX19) gene. Arsenic nudix hydrolase homolog 19 Arabidopsis thaliana
3 Arabidopsis thaliana Nudix hydrolase 19 (AtNUDX19) belongs to a family of proteins defined by the conserved amino-acid sequence GX5-EX7REUXEEXGU which has the capacity to hydrolyze NADPH as a physiological substrate in vivo. NADP nudix hydrolase homolog 19 Arabidopsis thaliana
4 Two major features were observed in the behavior of the main NADPH-recycling systems: (i) under optimal conditions in both organs, the levels of these activities were higher in nudx19 mutants than in Wt plants; and, (ii) under 500muM AsV conditions, these activities increase, especially in nudx19 mutant plants. NADP nudix hydrolase homolog 19 Arabidopsis thaliana
5 Two major features were observed in the behavior of the main NADPH-recycling systems: (i) under optimal conditions in both organs, the levels of these activities were higher in nudx19 mutants than in Wt plants; and, (ii) under 500muM AsV conditions, these activities increase, especially in nudx19 mutant plants. NADP nudix hydrolase homolog 19 Arabidopsis thaliana
6 Two major features were observed in the behavior of the main NADPH-recycling systems: (i) under optimal conditions in both organs, the levels of these activities were higher in nudx19 mutants than in Wt plants; and, (ii) under 500muM AsV conditions, these activities increase, especially in nudx19 mutant plants. asunaprevir nudix hydrolase homolog 19 Arabidopsis thaliana
7 In summary, the data reveals a connection between the absence of chloroplastic AtNUDX19 and the rise in all NADP-dehydrogenase activities under physiological and arsenic-induced stress conditions, particularly in roots. Arsenic nudix hydrolase homolog 19 Arabidopsis thaliana
8 This suggests that AtNUDX19 could be a key factor in modulating the NADPH pool in plants and consequently in redox homeostasis. NADP nudix hydrolase homolog 19 Arabidopsis thaliana