Title : Local delivery of controlled-release simvastatin to improve the biocompatibility of polyethylene terephthalate artificial ligaments for reconstruction of the anterior cruciate ligament.

Pub. Date : 2016

PMID : 26869789






1 Functional Relationships(s)
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1 Compared with the PET group and the COL/PET group, SIM could induce bone marrow stromal cells" osteoblastic differentiation, high alkaline phosphatase activity, more mineralization deposition, and more expression of osteoblast-related genes, such as osteocalcin, runt-related transcription factor 2, bone morphogenetic protein-2, and vascular endothelial growth factor, in the SIM/COL/PET group. Simvastatin osteocalcin Oryctolagus cuniculus