Title : Proteomics identification of PGAM1 as a potential therapeutic target for urothelial bladder cancer.

Pub. Date : 2016 Jan 30

PMID : 26655504






1 Functional Relationships(s)
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1 Moreover, we found, upon attenuation of PGAM1, its substrate 3-PG (3-phosphoglycerate) was up-regulated and product 2-PG (2-phosphoglycerate) was down-regulated, which consequently inhibited aerobic glycolysis and oxidative pentose phosphate pathway (PPP) that are essential to cancer cell proliferation. 2-phosphoglycerate phosphoglycerate mutase 1 Homo sapiens