Title : Effect of resveratrol and lipoic acid on sirtuin-regulated expression of metabolic genes in bovine liver and muscle slice cultures.

Pub. Date : 2015 Aug

PMID : 26440162






3 Functional Relationships(s)
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1 The objective of this study was to determine in bovine liver and muscle slice cultures the effect of RSV and LA treatment on the expresssion of Sirt1, Sirt3, peroxisome proliferator-activated receptor gamma coactivator 1alpha (PPARGC1A), and the forkhead box O transcription factors FoxO1 and FoxO3 as well as other factors involved in glucose and lipid metabolism and related to Sirt activity. Resveratrol sirtuin 1 Bos taurus
2 Our results show that the expression of the mRNA for Sirt1 was enhanced by RSV in liver under restriction ( <= 0.0112) and by LA in muscle, more under restriction ( <= 0.0121) than after epinephrine administration ( < 0.0001). Resveratrol sirtuin 1 Bos taurus
3 Our results show that the expression of the mRNA for Sirt1 was enhanced by RSV in liver under restriction ( <= 0.0112) and by LA in muscle, more under restriction ( <= 0.0121) than after epinephrine administration ( < 0.0001). Epinephrine sirtuin 1 Bos taurus