Pub. Date : 2015
PMID : 26191482
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study determined the effects of acute treatment with morphine on the expression of the Oprm1, Oprk1, and Oprd1 genes (which encode mu, kappa, and delta receptors, respectively) in the striatum, hypothalamus, and periaqueductal gray (PAG) in ovariectomized female rats treated with estrogen. | Morphine | opioid receptor, kappa 1 | Rattus norvegicus |
| 2 | Oprm1 and Oprk1 expression were activated, respectively, in the hypothalamus and PAG and in the striatum and PAG by morphine only in estrogen-treated animals. | Morphine | opioid receptor, kappa 1 | Rattus norvegicus |
| 3 | The Oprm1 and Oprk1 gene response to morphine might depend on estrogen, whereas the Oprd1 gene response to morphine might not depend on estrogen, supporting the hypothesis of a functional role for ovarian hormones in opioid receptor-mediated functional adaptations in the female brain. | Morphine | opioid receptor, kappa 1 | Rattus norvegicus |