Title : Neuropeptide Y differentiates between exocytotic and nonexocytotic noradrenaline release in guinea-pig heart.

Pub. Date : 1989 Nov

PMID : 2615846






7 Functional Relationships(s)
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1 Neuropeptide Y differentiates between exocytotic and nonexocytotic noradrenaline release in guinea-pig heart. Norepinephrine pro-neuropeptide Y Cavia porcellus
2 Exocytotic release: Electrical stimulation of the left stellate ganglion (12 Hz; 1 min) evoked a calcium-dependent overflow of noradrenaline and NPY, that was accompanied by a minor and prolonged increase in DOPEG overflow. Calcium pro-neuropeptide Y Cavia porcellus
3 In the presence of calcium, a closely related co-release of noradrenaline and NPY was also observed during administration of veratridine (10 microM); it was completely prevented by tetrodotoxin (1 microM). Calcium pro-neuropeptide Y Cavia porcellus
4 In the presence of calcium, a closely related co-release of noradrenaline and NPY was also observed during administration of veratridine (10 microM); it was completely prevented by tetrodotoxin (1 microM). Veratridine pro-neuropeptide Y Cavia porcellus
5 In the presence of calcium, a closely related co-release of noradrenaline and NPY was also observed during administration of veratridine (10 microM); it was completely prevented by tetrodotoxin (1 microM). Tetrodotoxin pro-neuropeptide Y Cavia porcellus
6 The results indicate that NPY is co-released with noradrenaline only during calcium-dependent exocytosis. Norepinephrine pro-neuropeptide Y Cavia porcellus
7 The results indicate that NPY is co-released with noradrenaline only during calcium-dependent exocytosis. Calcium pro-neuropeptide Y Cavia porcellus