Pub. Date : 2015 Aug
PMID : 26116439
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The antidepressant-like activity of nicotine, but not of 3-furan-2-yl-N-p-tolyl-acrylamide, is regulated by the nicotinic receptor beta4 subunit. | Nicotine | basic helix-loop-helix family, member e23 | Mus musculus |
| 2 | Our results indicate that nicotine mediates antidepressant-like activity after acute, subchronic, and chronic treatments in beta4+/+, but not beta4-/-, mice, and that these effects are not mediated by unspecific locomotor stimulation. | Nicotine | basic helix-loop-helix family, member e23 | Mus musculus |
| 3 | Nicotine co-administered with PAM-2 produces antidepressant-like activity in both beta4+/+ and beta4-/- mice, except after the acute treatment of beta4-/- mice, and decreases locomotor activity. | Nicotine | basic helix-loop-helix family, member e23 | Mus musculus |
| 4 | Nicotine co-administered with PAM-2 produces antidepressant-like activity in both beta4+/+ and beta4-/- mice, except after the acute treatment of beta4-/- mice, and decreases locomotor activity. | Nicotine | basic helix-loop-helix family, member e23 | Mus musculus |
| 5 | Nicotine co-administered with PAM-2 produces antidepressant-like activity in both beta4+/+ and beta4-/- mice, except after the acute treatment of beta4-/- mice, and decreases locomotor activity. | Nicotine | basic helix-loop-helix family, member e23 | Mus musculus |
| 6 | This suggests that although the beta4 subunit regulates the antidepressant-like activity of nicotine it does not affect the activity elicited by PAM-2 when is co-administered with nicotine. | Nicotine | basic helix-loop-helix family, member e23 | Mus musculus |
| 7 | Our findings clearly indicate that beta4-containing nAChRs play an important role in the antidepressant-like activity elicited by nicotine but they are not essential for the modulatory activity of PAM-2. | Nicotine | basic helix-loop-helix family, member e23 | Mus musculus |