Title : Engineering of yeast pyruvate decarboxylase for enhanced selectivity towards carboligation.

Pub. Date : 2015 Sep

PMID : 26022970






2 Functional Relationships(s)
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1 Over-expression of mutant Pdc1 resulted in 50 +- 2.5% increase in levels of (R)-PAC in wild-type and further 30-40% in pdc null background. (R)-1-Hydroxy-1-phenylacetone indolepyruvate decarboxylase 1 Saccharomyces cerevisiae S288C
2 The combination of mutant Pdc1 in pdc null background was successfully evaluated for production of (R)-PAC at industrial scale. (R)-1-Hydroxy-1-phenylacetone indolepyruvate decarboxylase 1 Saccharomyces cerevisiae S288C