Title : Dual targeting of mTORC1 and mTORC2 by INK-128 potently inhibits human prostate cancer cell growth in vitro and in vivo.

Pub. Date : 2015 Sep

PMID : 25990456






2 Functional Relationships(s)
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1 INK-128-induced prostate cancer cell apoptosis and cytotoxicity were alleviated upon pretreatment of cells with the pan-caspase inhibitor z-VAD-FMK or the specific caspase-3 inhibitor z-DVED-FMK. INK128 caspase 3 Homo sapiens
2 In vivo, oral administration of INK-128 significantly inhibited growth of PC-3 xenografts in nude mice. INK128 BTG anti-proliferation factor 2 Homo sapiens