Pub. Date : 1989 Oct 15
PMID : 2597113
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of apolipoprotein B net synthesis and secretion from cultured rat hepatocytes by the calcium-channel blocker diltiazem. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 2 | The effect of the Ca2+-channel blocker diltiazem on hepatic apolipoprotein B (apo B) synthesis and secretion was studied in 12-18 h cultures of collagenase-dispersed rat hepatocytes. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 3 | The effect of the Ca2+-channel blocker diltiazem on hepatic apolipoprotein B (apo B) synthesis and secretion was studied in 12-18 h cultures of collagenase-dispersed rat hepatocytes. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 4 | The presence of diltiazem in the medium decreased apo B secretion by hepatocytes in a concentration-dependent manner. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 5 | At 25 microM, diltiazem inhibited apo B secretion by approx. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 6 | The inhibition of apo B secretion by hepatocytes was significantly correlated with cell-associated diltiazem (r = 0.72, P less than 0.01). | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 7 | The rate of apo B secretion remained linear over 16 h even in the presence of 50 microM-diltiazem. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 8 | At diltiazem concentrations in the medium which were inhibitory for apo B secretion, [14C]acetate incorporation into cellular lipids and [35S]methionine incorporation into protein were enhanced. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 9 | Diltiazem inhibited the secretion of the apo B variants with a preferential inhibition of the higher-molecular-mass form of apo B (apo BH) over the lower-molecular-mass form (apo BL) at diltiazem concentrations in the medium greater than 25 microM. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 10 | Diltiazem inhibited the secretion of the apo B variants with a preferential inhibition of the higher-molecular-mass form of apo B (apo BH) over the lower-molecular-mass form (apo BL) at diltiazem concentrations in the medium greater than 25 microM. | Diltiazem | apolipoprotein B | Rattus norvegicus |
| 11 | Diltiazem inhibited the secretion of the apo B variants with a preferential inhibition of the higher-molecular-mass form of apo B (apo BH) over the lower-molecular-mass form (apo BL) at diltiazem concentrations in the medium greater than 25 microM. | Diltiazem | apolipoprotein B | Rattus norvegicus |