Title : Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy.

Pub. Date : 2015 Apr 3

PMID : 25919711






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tafazzin (TAZ) is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Phospholipids tafazzin, phospholipid-lysophospholipid transacylase Mus musculus
2 Tafazzin (TAZ) is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Phospholipids tafazzin, phospholipid-lysophospholipid transacylase Mus musculus
3 Using primary mouse embryonic fibroblasts (MEFs) with doxycycline-inducible knockdown of Taz, we showed that TAZ deficiency in MEFs caused defective mitophagosome biogenesis, but not other autophagic processes. Doxycycline tafazzin, phospholipid-lysophospholipid transacylase Mus musculus
4 Using primary mouse embryonic fibroblasts (MEFs) with doxycycline-inducible knockdown of Taz, we showed that TAZ deficiency in MEFs caused defective mitophagosome biogenesis, but not other autophagic processes. Doxycycline tafazzin, phospholipid-lysophospholipid transacylase Mus musculus