Pub. Date : 2015 Aug
PMID : 25863674
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We determined whether brimonidine modulates axonal loss induced by TNF and affects the expression of p62 in the optic nerve. | Brimonidine Tartrate | KH RNA binding domain containing, signal transduction associated 1 | Rattus norvegicus |
| 2 | Immunoblot analysis showed that p62 was upregulated in the optic nerve after intravitreal injection of TNF, and that this increase was completely inhibited by brimonidine. | Brimonidine Tartrate | KH RNA binding domain containing, signal transduction associated 1 | Rattus norvegicus |
| 3 | Treatment with brimonidine alone also significantly decreased p62 protein levels in the optic nerve compared with the basal level. | Brimonidine Tartrate | KH RNA binding domain containing, signal transduction associated 1 | Rattus norvegicus |
| 4 | CONCLUSIONS: These results suggest that the modulation of p62 levels in the optic nerve by brimonidine may be involved partly in its axonal protection. | Brimonidine Tartrate | KH RNA binding domain containing, signal transduction associated 1 | Rattus norvegicus |