Pub. Date : 2015 Apr 7
PMID : 25843711
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. | bis(3',5')-cyclic diguanylic acid | stimulator of interferon response cGAMP interactor 1 | Homo sapiens |
| 2 | Here, we report that c-di-GMP comprehensively regulated both HSPCs and their niche cells through an innate immune sensor, STING, thereby inducing entry into the cell cycle and mobilization of HSPCs while decreasing the number and repopulation capacity of long-term hematopoietic stem cells. | bis(3',5')-cyclic diguanylic acid | stimulator of interferon response cGAMP interactor 1 | Homo sapiens |
| 3 | Furthermore, we show that type I interferon acted as a downstream target of c-di-GMP to inhibit HSPC expansion in the spleen, while transforming growth factor-beta was required for c-di-GMP-dependent splenic HSPC expansion. | bis(3',5')-cyclic diguanylic acid | proteasome 20S subunit alpha 7 | Homo sapiens |
| 4 | Furthermore, we show that type I interferon acted as a downstream target of c-di-GMP to inhibit HSPC expansion in the spleen, while transforming growth factor-beta was required for c-di-GMP-dependent splenic HSPC expansion. | bis(3',5')-cyclic diguanylic acid | proteasome 20S subunit alpha 7 | Homo sapiens |
| 5 | Our results define machinery underlying the dynamic regulation of HSPCs and their niches during bacterial infection through c-di-GMP/STING signaling. | bis(3',5')-cyclic diguanylic acid | stimulator of interferon response cGAMP interactor 1 | Homo sapiens |