Title : Cholinergic capacity mediates prefrontal engagement during challenges to attention: evidence from imaging genetics.

Pub. Date : 2015 Mar

PMID : 25536497






1 Functional Relationships(s)
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1 Specifically, we scanned (BOLD fMRI) participants with a polymorphism of the choline transporter gene that is thought to limit choline transport capacity (Ile89Val variant of the choline transporter gene SLC5A7, rs1013940) and matched controls while they completed a task previously used to demonstrate demand-related increases in right PFC cholinergic transmission in rats and right PFC activation in humans. Choline solute carrier family 5 member 7 Homo sapiens