Pub. Date : 2015 Jan
PMID : 25475787
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | With the use of a culture system that we developed (fetal testis assay [FeTA]), we previously showed that 10 nmol/L BPA reduces basal testosterone secretion of human fetal testis explants and that the susceptibility to BPA is at least 100-fold lower in rat and mouse fetal testes. | bisphenol A | ATPase, class I, type 8B, member 5 | Mus musculus |
| 2 | With the use of a culture system that we developed (fetal testis assay [FeTA]), we previously showed that 10 nmol/L BPA reduces basal testosterone secretion of human fetal testis explants and that the susceptibility to BPA is at least 100-fold lower in rat and mouse fetal testes. | Testosterone | ATPase, class I, type 8B, member 5 | Mus musculus |
| 3 | Here, we show that addition of LH in the FeTA system considerably enhances BPA minimum effective concentration in mouse and human but not in rat fetal testes. | Luteinizing Hormone | ATPase, class I, type 8B, member 5 | Mus musculus |
| 4 | Here, we show that addition of LH in the FeTA system considerably enhances BPA minimum effective concentration in mouse and human but not in rat fetal testes. | bisphenol A | ATPase, class I, type 8B, member 5 | Mus musculus |
| 5 | Then, using the FeTA system without LH (the experimental conditions in which mouse and human fetal testes are most sensitive to BPA), we found that, as for BPA, 10 nmol/L BPS or BPF is sufficient to decrease basal testosterone secretion by human fetal testes with often nonmonotonic dose-response curves. | bis(4-hydroxyphenyl)sulfone | ATPase, class I, type 8B, member 5 | Mus musculus |
| 6 | Then, using the FeTA system without LH (the experimental conditions in which mouse and human fetal testes are most sensitive to BPA), we found that, as for BPA, 10 nmol/L BPS or BPF is sufficient to decrease basal testosterone secretion by human fetal testes with often nonmonotonic dose-response curves. | bisphenol F | ATPase, class I, type 8B, member 5 | Mus musculus |