Title : Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

Pub. Date : 2014 Oct 9

PMID : 25229643






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Ultimately, these efforts led to the identification of ML323 (70) and related N-benzyl-2-phenylpyrimidin-4-amine derivatives, which possess nanomolar USP1/UAF1 inhibitory potency. ML323 ubiquitin specific peptidase 1 Homo sapiens
2 Ultimately, these efforts led to the identification of ML323 (70) and related N-benzyl-2-phenylpyrimidin-4-amine derivatives, which possess nanomolar USP1/UAF1 inhibitory potency. ML323 WD repeat domain 48 Homo sapiens