Title : Sildenefil increases connexin 40 in smooth muscle cells through activation of BMP pathways in pulmonary arterial hypertension.

Pub. Date : 2014

PMID : 25197339






1 Functional Relationships(s)
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1 These phenomenon are reversed by LDN-193189, the antagonist of type II receptor for bone morphogenetic protein (BMPR2) treatment, providing strong evidence for the protect effect of sildenafil and the BMP-Cx40 axis involvement. Sildenafil Citrate bone morphogenetic protein receptor type 2 Rattus norvegicus