Title : Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche.

Pub. Date : 2015 Jan

PMID : 25048519






2 Functional Relationships(s)
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1 Our working hypothesis, to be discussed and partially tested herein, is that CD38, and likely BST1/CD157--both NAD(+) -consuming enzymes, are active in the myeloma niche and lead a discontinuous chain of ectoenzymes whose final products are exploited by the neoplastic plasma cell as part of its local survival strategy. NAD bone marrow stromal cell antigen 1 Homo sapiens
2 Our working hypothesis, to be discussed and partially tested herein, is that CD38, and likely BST1/CD157--both NAD(+) -consuming enzymes, are active in the myeloma niche and lead a discontinuous chain of ectoenzymes whose final products are exploited by the neoplastic plasma cell as part of its local survival strategy. NAD bone marrow stromal cell antigen 1 Homo sapiens