Pub. Date : 2014 Nov
PMID : 25044854
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS AND RESULTS: ABCG2-inhibitory activity of xanthohumol (XN), isoxanthohumol (IX), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), and 6,8-diprenylnarigenin (6,8-diPN) was evaluated using mitoxantrone accumulation and vesicular transport assays. | xanthohumol | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 2 | METHODS AND RESULTS: ABCG2-inhibitory activity of xanthohumol (XN), isoxanthohumol (IX), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), and 6,8-diprenylnarigenin (6,8-diPN) was evaluated using mitoxantrone accumulation and vesicular transport assays. | 8-prenylnaringenin | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 3 | METHODS AND RESULTS: ABCG2-inhibitory activity of xanthohumol (XN), isoxanthohumol (IX), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), and 6,8-diprenylnarigenin (6,8-diPN) was evaluated using mitoxantrone accumulation and vesicular transport assays. | 6,8-diprenylnarigenin | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 4 | METHODS AND RESULTS: ABCG2-inhibitory activity of xanthohumol (XN), isoxanthohumol (IX), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), and 6,8-diprenylnarigenin (6,8-diPN) was evaluated using mitoxantrone accumulation and vesicular transport assays. | 6,8-dipn | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 5 | METHODS AND RESULTS: ABCG2-inhibitory activity of xanthohumol (XN), isoxanthohumol (IX), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), and 6,8-diprenylnarigenin (6,8-diPN) was evaluated using mitoxantrone accumulation and vesicular transport assays. | Mitoxantrone | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 6 | XN, IX, and 8-PN were tested for a substrate-type relationship with ABCG2 using ATPase and bidirectional transport assays. | 8-prenylnaringenin | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 7 | The prenylflavonoids exhibited significant ABCG2-inhibitory activities in mitoxantrone accumulation and vesicular transport assays. | Mitoxantrone | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 8 | The latter was reduced to 1.25 +- 0.15 in the presence of the ABCG2-specific inhibitor Ko143, demonstrating an ABCG2-mediated efflux of IX. | 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 9 | The latter was reduced to 1.25 +- 0.15 in the presence of the ABCG2-specific inhibitor Ko143, demonstrating an ABCG2-mediated efflux of IX. | 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 10 | Additionally, evidence was shown for the involvement of ABCG2 in the efflux of 8-PN and/or its sulfate conjugate. | 8-prenylnaringenin | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |
| 11 | Additionally, evidence was shown for the involvement of ABCG2 in the efflux of 8-PN and/or its sulfate conjugate. | Sulfates | ATP binding cassette subfamily G member 2 | Canis lupus familiaris |