Pub. Date : 1989 Apr 15
PMID : 2495173
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin H synthase (PHS), an arachidonic acid-dependent peroxidase, has been implicated in the peroxidative activation of carcinogenic aromatic amines in extrahepatic carcinogen target tissues of experimental animals. | aromatic amines | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 2 | Prostaglandin H synthase (PHS), an arachidonic acid-dependent peroxidase, has been implicated in the peroxidative activation of carcinogenic aromatic amines in extrahepatic carcinogen target tissues of experimental animals. | aromatic amines | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 3 | For several samples of urinary bladder epithelium, prostatic epithelium, colonic mucosa, and peripheral lung tissue, an arachidonic acid-dependent, microsomal-catalyzed activation of benzidine was observed; and the activity could be inhibited appreciably by indomethacin, a known inhibitor of PHS. | Arachidonic Acid | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 4 | For several samples of urinary bladder epithelium, prostatic epithelium, colonic mucosa, and peripheral lung tissue, an arachidonic acid-dependent, microsomal-catalyzed activation of benzidine was observed; and the activity could be inhibited appreciably by indomethacin, a known inhibitor of PHS. | benzidine | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 5 | Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole. | benzidine | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 6 | Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole. | 2-Naphthylamine | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 7 | Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole. | 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 8 | Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole. | 4-aminobiphenyl greater | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 9 | Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole. | 2-amino-3-methylimidazo(4,5-f)quinoline | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 10 | Purified PHS catalyzed the activation of benzidine much greater than 2-naphthylamine, 2-amino-6-methyldipyrido[1,2-alpha:3",2"-d]imidazole greater than 4-aminobiphenyl greater than 2-amino-3-methylimidazo[4,5-f]quinoline greater than 3-amino-1-methyl-5H-pyrido[4,3-b] indole. | 3-amino-1-methyl-5H-pyrido(4,3-b)indole | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 11 | The avidin/biotin-amplified enzyme-linked immunosorbent assay, which detected ng quantities of ram PHS, clearly established the presence of the PHS protein in human bladder, prostate, and lung microsomes. | Biotin | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 12 | The avidin/biotin-amplified enzyme-linked immunosorbent assay, which detected ng quantities of ram PHS, clearly established the presence of the PHS protein in human bladder, prostate, and lung microsomes. | Biotin | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 13 | The interindividual and tissue-dependent variability of PHS and its role in aromatic amine carcinogenesis are discussed. | aromatic amine | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |