Title : MicroRNA miR-320a modulates induction of HO-1, GCLM and OKL38 by oxidized phospholipids in endothelial cells.

Pub. Date : 2014 Jul

PMID : 24786516






11 Functional Relationships(s)
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1 MicroRNA miR-320a modulates induction of HO-1, GCLM and OKL38 by oxidized phospholipids in endothelial cells. Phospholipids microRNA 615 Mus musculus
2 miR-320a levels were changed by transfection with synthetic oligonucleotides. Oligonucleotides microRNA 615 Mus musculus
3 RESULTS: Oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) induced miR-320a in endothelial cells. palmitoyl-arachidonoyl-phosphatidylcholine microRNA 615 Mus musculus
4 RESULTS: Oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) induced miR-320a in endothelial cells. oxpapc microRNA 615 Mus musculus
5 Induction of HO-1, OKL38 and GCLM mRNAs by OxPAPC and sulforaphane was attenuated upon knockdown of miR-320a. sulforaphane microRNA 615 Mus musculus
6 In contrast, transfection of ECs with miR-320a mimic oligonucleotide potentiated the effects of OxPAPC and sulforaphane on induction of HO-1, OKL38 and GCLM mRNAs. Oligonucleotides microRNA 615 Mus musculus
7 In contrast, transfection of ECs with miR-320a mimic oligonucleotide potentiated the effects of OxPAPC and sulforaphane on induction of HO-1, OKL38 and GCLM mRNAs. oxpapc microRNA 615 Mus musculus
8 In contrast, transfection of ECs with miR-320a mimic oligonucleotide potentiated the effects of OxPAPC and sulforaphane on induction of HO-1, OKL38 and GCLM mRNAs. sulforaphane microRNA 615 Mus musculus
9 OxPAPC-induced p38 activation, levels of NRF2 protein and its ability to bind to consensus NRF2 DNA binding site were elevated in ECs transfected with miR-320a mimic. oxpapc microRNA 615 Mus musculus
10 CONCLUSION: miR-320a plays important role in induction of expression of HO-1, GCLM and OKL38 upon ESR induced either by OxPAPC or sulforaphane. oxpapc microRNA 615 Mus musculus
11 CONCLUSION: miR-320a plays important role in induction of expression of HO-1, GCLM and OKL38 upon ESR induced either by OxPAPC or sulforaphane. sulforaphane microRNA 615 Mus musculus