Pub. Date : 2014 Jun
PMID : 24698107
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Loss of B-cell translocation gene 2 expression in estrogen receptor-positive breast cancer predicts tamoxifen resistance. | Tamoxifen | BTG anti-proliferation factor 2 | Homo sapiens |
| 2 | BTG2 inhibits the expression of HER ligands and promotes AKT activation, which plays an essential role in the tamoxifen resistance of estrogen receptor (ER)-positive breast cancer. | Tamoxifen | BTG anti-proliferation factor 2 | Homo sapiens |
| 3 | Tamoxifen suppressed the human epidermal growth factor receptor 2 (HER2)-Akt signaling in BTG2 expressing ER-positive breast cancer cells with a correlated increase in sensitivity, whereas BTG2 knockdown abrogated this sensitivity. | Tamoxifen | BTG anti-proliferation factor 2 | Homo sapiens |
| 4 | These studies demonstrate that BTG2 is a significant factor in tamoxifen response, acting through modification of AKT activation in ER-positive/HER2-negative breast cancer. | Tamoxifen | BTG anti-proliferation factor 2 | Homo sapiens |